Abstract

• In this reseach, the Claisen-Schmidth reaction was applied to 2-indanone and the

α,β-unsaturated carbonyl compounds were obtained

• The spiro epoxides corresponding to the previously synthetic β, α-unsaturated carbonyl compounds were prepared according to the Pine reaction, where the epoxide was formed as the sole product. All the synthesis reactions were performed in methanol as it was the most suitable reaction medium

• The best yield of epoxide was obtained in the presence of (β, α-unsaturated ketones: acetonitrile: oxygen water (1:4:4), respectively, and at room temperature.

• Spiro acetones have been synthesized, corresponding to the previously prepared spiro epoxides, which have great biological benefits. The importance of this research lies in the fact that the new synthetic compounds are spiro compounds.

• The structure of all the synthetic compounds was confirmed by IR and NMR. spectroscopic methods

Keywords: epoxides – acetonides – indenone – oxygen nucleophiles